Epitope prediction

This page allows you to find out the ligation strength to a defined HLA type for a sequence of aminoacids. The algorithmus used are based on the book "MHC Ligands and Peptide Motifs" by H.G.Rammensee, J.Bachmann and S.Stevanovic. The probability of being processed and presented is given in order to predict T-cell epitopes.

1. Select MHC type(s)		2. Paste a sequence (mandatory)
H2-Ad (15) Mouse H2-Ak (15) Mouse H2-Db (9,10) Mouse H2-Ed (15) Mouse H2-Ek (15) Mouse H2-Kb (8) Mouse H2-Kd (9,10) Mouse H2-Kk (8,9) Mouse H2-Ld (9) Mouse HLA-A*01:01 (9,10,11,12,13) Human HLA-A*02:01 (9,10,11) Human HLA-A*03:01 (9,10,11) Human HLA-A*11:01 (9,10,11) Human HLA-A*24:02 (9,10,11) Human HLA-A*26:01 (9,10,11) Human HLA-A*31:01 (9,10,11) Human HLA-A*32:01 (9,10,11) Human HLA-A*33:03 (9,10,11) Human HLA-A*66:01 (9,10) Human HLA-A*68:01 (9,10,11) Human HLA-B*07:02 (9,10,11) Human HLA-B*08:01 (8,9) Human HLA-B*13:02 (9,10) Human HLA-B*14:02 (8,9) Human HLA-B*15:01 (B62) (9,10) Human HLA-B*15:10 (9) Human HLA-B*15:16 (9) Human HLA-B*18:01 (8,9) Human HLA-B*27:05 (9,10) Human HLA-B*27:09 (9) Human HLA-B*35:01 (9,10) Human HLA-B*37:01 (8,9,10) Human HLA-B*38:01 (9,10) Human HLA-B*39:01 (9,10) Human HLA-B*39:02 (9,10) Human HLA-B*40:01 (B60) (9,10) Human HLA-B*41:01 (9,10) Human HLA-B*44:02 (9,10,11) Human HLA-B*45:01 (9,10) Human HLA-B*47:01 (9,10) Human HLA-B*49:01 (9,10) Human HLA-B*50:01 (9,10) Human HLA-B*51:01 (8,9) Human HLA-B*53:01 (9,10) Human HLA-B*57:01 (9,10) Human HLA-B*58:01 (8,9,10,11) Human HLA-B*58:02 (8,9,10,11) Human HLA-C*01:02 (8,9,10) Human HLA-C*02:02 (8,9,10) Human HLA-C*03:03 (8,9,10) Human HLA-C*03:04 (8,9,10) Human HLA-C*04:01 (8,9,10) Human HLA-C*05:01 (8,9,10) Human HLA-C*06:01 (9) Human HLA-C*06:02 (8,9,10) Human HLA-C*07:01 (8,9,10) Human HLA-C*07:02 (8,9,10) Human HLA-C*08:02 (10,8,9) Human HLA-C*12:03 (8,9,10) Human HLA-C*14:02 (8,9,10) Human HLA-C*15:02 (8,9,10) Human HLA-C*16:01 (8,9,10) Human HLA-C*17:01 (8,9,10) Human HLA-DRB1*01:01 (15,9) Human HLA-DRB1*03:01 (9) Human HLA-DRB1*03:01 (DR17) (15) Human HLA-DRB1*04:01 (DR4Dw4) (15) Human HLA-DRB1*07:01 (15,9) Human HLA-DRB1*11:01 (15,9) Human HLA-DRB1*15:01 (9) Human HLA-DRB1*15:01 (DR2b) (15) Human HLA-G*01:01 (8,9,10) Human Rano-A*l (9) Rat		SYFPEITHI Max. input is 2048 aminoacids (letters). Letters only, no numbers or non-Letter-symbols, please. Blanks and line-breaks are ignored. You may use 'SYFPEITHI' with H2-Kd to see an example.
		3. Choose one or several amino acid frame length(s)
		octamers (8 aa) nonamers (9 aa) decamers (10 aa) endecamers (11 aa) dodecamers (12 aa) tridecamers (13 aa) pentadecamers (15 aa) for MHC Type II only any aa frame length (8-15 aa) Minimum Score
		4. Choose run to start analysis
You may select up to three different MHC-types. Just hold down the Ctrl (windows) or Command (Mac) button when clicking on a MHC.		clear input go to Home page